Pharmaceutical XRD Testing
Ensure your pharmaceutical products' safety, efficacy, and regulatory compliance with precise X-ray Powder Diffraction testing. When you need accurate crystalline structure analysis with minimal sample quantities, Element's 30+ years of expertise, advanced Empyrean technology, and dual-geometry capabilities deliver critical insights without sample preparation, accelerating your development timelines while ensuring data integrity.
What is Pharmaceutical XRD Testing testing at element ?
X-ray Powder Diffraction (XRPD) is an analytical technique that identifies and characterizes crystalline materials by measuring how X-rays diffract through crystalline structures in powder samples. At Element, we leverage this powerful technique as leaders in the field of X-ray Powder Diffraction (XRPD) analysis to provide detailed crystallographic information crucial for pharmaceutical development, formulation stability, and regulatory compliance, helping you understand your products at the molecular level.
What can Element offer you for Pharmaceutical XRD Testing?
Materials We Test
Materials We Test
Our comprehensive XRPD testing capabilities extend across a wide range of pharmaceutical materials, from raw APIs to finished dosage forms. We specialize in analyzing challenging samples including those prone to preferred orientation effects such as needle or platelet structures. Our expertise allows us to test with minimal sample amounts—less than 10mg—making us ideal for valuable or limited-quantity materials.
Key Tests Offered
Key Tests Offered
We provide a comprehensive suite of X-ray diffraction analyses tailored to pharmaceutical needs. Our services include:
- Powder Diffraction
- Phase Identification
- API Limit Testing
- Percent Crystallinity
- Identification of Pharmaceutical Powders
- Foreign Phases Analysis
- Stability Projects to Ensure Stable Crystalline Structure
- Quantitative Analysis of Mixtures of Crystal Forms
- Analysis of Inorganic Products Such as Corrosion Products (e.g. Ceramics and Clay)
Solutions Offered
Solutions Offered
Element offers both reflection and transmission geometry XRPD methods, giving you flexibility based on your specific sample requirements. Our transmission geometry capability is particularly valuable for solving problems in traditional reflection geometry when analyzing pharmaceuticals, proteins, polymers, powders prone to preferred orientation effects (such as needles or platelets), liquid dispersions or slurries, and air sensitive or hazardous materials. You'll benefit from our ability to analyze samples without preparation—tablets, capsules, creams, and suspensions can be tested directly, streamlining your process.
Cutting-edge Equipment We Use
Cutting-edge Equipment We Use
We employ the Malvern Panalytical third-generation Empyrean X-ray diffractometer, providing exceptionally high-resolution diffraction patterns efficiently. This state-of-the-art instrument includes the latest crystallographic database for reliable identification of unknown compounds and is complemented by CFR Part 21 compliant software—ensuring both accuracy and regulatory acceptance.
Standards we test to and materials we test
- Active Pharmaceutical Ingredients (APIs)
- Drug formulations and finished products
- Pharmaceutical powders
- Crystalline structures
- Tablets and capsules
- Creams and ointments
- Suspensions
- Corrosion products
- Inorganic materials (ceramics and clay)
- Proteins and polymers
- Liquid dispersions or slurries
- Air sensitive or hazardous materials
Your Challenges, Our Solutions
Regulatory Documentation Needs
Tight Development Timelines
Accurate Phase Identification
Limited Sample Availability
Why Choose Element
Pharmaceutical Market Leaders
Minimal Sample Requirements
Dual Analysis Methods
No Sample Preparation
30+years
<10mg minimum
3rdgeneration
21 CFR
Frequently asked questions
What is transmission geometry XRPD and when should it be used?
Transmission geometry XRPD is a specialized approach where X-rays pass through samples rather than reflecting off surfaces. This method is particularly valuable for pharmaceuticals, proteins, polymers, and materials with orientation effects like needle or platelet structures. It's also ideal for analyzing liquid dispersions, slurries, and air-sensitive or hazardous materials that pose challenges in traditional reflection geometry.
How much sample is required for XRPD analysis?
Our advanced instrumentation can analyze samples as small as 10mg or less while still generating high-quality diffraction patterns. This makes our service ideal when testing valuable APIs, limited research quantities, or expensive materials during development phases.
How does Element ensure regulatory compliance with XRD testing data?
Element uses CFR Part 21 compliant software throughout the testing process, ensuring data integrity and traceability required by regulatory agencies. Our comprehensive documentation approach and 30+ years of experience in pharmaceutical testing means we understand exactly what regulators need to see in your submissions.
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