Nuclear Magnetic Resonance (NMR) Spectroscopy in Pharmaceutical Analysis

Meet regulatory requirements and ensure product quality through our comprehensive Nuclear Magnetic Resonance (NMR) Spectroscopy in Pharmaceutical Analysis services. From compound verification to impurity testing, our cGMP-compliant NMR solutions deliver precise structural analysis and quantitative measurements that accelerate your pharmaceutical development process while maintaining compliance standards.

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What is Nuclear Magnetic Resonance (NMR) Spectroscopy in Pharmaceutical Analysis at Element?

NMR Spectroscopy is an advanced analytical technique that provides detailed information about molecular covalent structure, stereochemistry, and conformation. At Element, we provide cGMP-compliant NMR services that enable verification of chemical synthesis, compound characterization, and impurity analysis, ensuring your product meets regulatory requirements while supporting critical stages of your pharmaceutical development process.

What can Element offer you for NMR in Pharmaceutical Analysis?

Materials we test

Our NMR analysis capabilities cover a wide range of pharmaceutical materials, from APIs to complex polymers. We specialize in analyzing biodegradable polymers, polysaccharides, synthetic peptides, and various pharmaceutical compounds, providing you with comprehensive structural and quantitative data.

Key tests offered

Complete structural elucidations
Impurity determinations
Co-monomer ratio analysis
Residual monomer analysis
Degree of substitution measurements
Weight percent analysis
Sequence confirmation

Methods and solutions offered

Our Nuclear Magnetic Resonance Spectroscopy services include:

Heparin Sodium impurity determinations
Identification, co-monomer ratios and residual monomer analysis of biodegradable polymers such as PLGA
Determination of weight percent oxyethylene in poloxamers
Olefins in crude oils and condensates
Deacetylation degree of polysaccharides such as Chitosan
Confirmation of synthetic peptide sequence
Complete structural elucidations of Active Pharmaceutical Ingredients (API) and naturally occurring compound and in-process impurities
Structural elucidations studies involve 1D, 1H, 13C, 31P and 19F NMR in combination with 2D {1H, 1H} (COSY, TOCSY, NOESY), 2D {1H, 13C} and {1H, 15N} HSQC and HMBC and 2D {19F, 13C} HSMBC experiments.

We employ multiple NMR techniques including:

1D, 1H, 13C, 31P and 19F NMR
2D {1H, 1H} (COSY, TOCSY, NOESY)
2D {1H, 13C} and {1H, 15N} HSQC and HMBC
2D {19F, 13C} HSMBC experiments

Which labs offer this service

Our team operates from Life Sciences hubs across the world, providing global access to our expert capabilities. Find your nearest Life Sciences hub on our Locations Page.

Complex mixture analysis expertise

Our NMR capabilities extend beyond single-compound analysis to analyze complex mixtures of compounds that are often amenable to NMR analysis, giving you comprehensive insights into multi-component pharmaceutical formulations. This capability is particularly valuable when dealing with combination products or investigating impurity profiles.

Materials we test

These are our most prevalent requests. Don't see what you're looking for? Contact us!

Pharmaceutical Materials:

Active Pharmaceutical Ingredients (APIs)
Drug substances
Excipients
Natural compounds
In-process impurities

Polymers:

Biodegradable polymers (PLGA)
Poloxamers
Polysaccharides (Chitosan)
Synthetic peptides

Other:

Heparin Sodium
Crude oils and condensates

Your Challenges, Our Solutions

Regulatory Compliance Concerns

Our cGMP-compliant NMR system ensures your testing meets regulatory requirements while providing documented verification of chemical compounds and impurity determinations.

Quality Assurance Complexity

Access comprehensive compound characterization and impurity analysis services that verify your chemical synthesis accuracy and identify potential issues early.

Complex Structural Analysis Needs

Utilize our multi-technique NMR approach combining 1D and 2D experiments to get complete structural information about your compounds.

Precise Measurement Requirements

Benefit from both absolute and relative quantitative measurements that determine exact co-monomer ratios and degrees of substitution in your materials.